ea0020p447 | Obesity and Metabolism | ECE2009
Roman Erika Anne
, Reis Daniel
, Romanatto Talita
, Maimoni Denis
, Solon Carina
, Morari Joseane
, Velloso Licio Augusto
, Torsoni Marcio Alberto
Leptin is an adipocyte-derived hormone that acts directly in the brain reducing food intake, increasing glucose uptake and modulating the metabolism in adipose tissue. Nevertheless, the central mechanisms related to improve glucose uptake, induced by leptin intracerebroventricular (icv), and the proteins activated in the skeletal muscle are incompletely understood. The aim of this study was to investigate the mechanism by which ICV leptin increase glucose uptake and improve gl...